MPTP Neurotoxicity Syndromes

《英文msh詞典》MPTP Neurotoxicity Syndromes
[入口詞] MPTP Neurotoxicity Syndromes
[主題詞] MPTP Poisoning
[英文釋義] A condition caused by the neurotoxin 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. MPTP causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE,SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al.,Principles of Neurology,6th ed,p1072; Neurology 1986 Feb;36(2):250-8)